Biomedical Engineering Reference
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1 m
5 00 m
b)
a)
Figure 8.24 Spherical pore network inside a PLCL 2D substrate.
8.7.5
Fabrication of a Tubular Scaffold
Figure 8.25 shows a fabrication process of a PLCL tubular scaffold.
A tube with arbitrary wall thickness (inner diameter >1 mm) as a
sacriicial model can be prepared as described previously (Fig.
8.25(a)), [42]. Then a PLCL sheet-like scaffold was rolled around
the tube with several millimeters' overlap (Figs. 8.25(b-c)). After
winding, the boundary of inner and outer sheet was welded by original
polymer solution (PLCL 10 w% in chloroform [Figure 8.25(d)]).
After the dissolution of sacriicial tube model, we obtained a PLCL
cylindrical scaffold with controlled pore layouts (Fig. 8.25(e)).
Tube Model
PLCL sheet
PLCL tube
Pore assembly
a)
b)
c)
d)
e)
Figure 8.25 Fabrication process of a tubular scaffold (a) Tube model was
obtained by lost-wax method (b-c) PLCL sheet with pores was
rolled around the tube model. (d) The edge line of PLCL sheet
was welded by original PLCL solution. (e) After the dissolution
of the tube model, PLCL tubular construct with porous
coniguration was obtained.
Sheet-like scaffolds of the previous section were used to fabricate
tubular scaffolds. Scaffolds were rolled around the tube models and
the edge line between inner and outer layer was welded by original
PLCL solution. After drying and dissolution of the tube model,
tubular scaffolds were successfully obtained as shown in Fig. 8.26.
 
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