Biomedical Engineering Reference
In-Depth Information
sheet-like scaffolds and membrane thickness of the cylindrical
scaffolds were measured by adjusting parameters of porosity,
polymer concentration, and pull-up velocity. The biocompatibility of
scaffolds was conirmed by the growth of HUVECs on the scaffolds.
The proposed fabrication technique has three features that make
it attractive:
(i) It can create patient-speciic arterial scaffolds with >1 mm
inner diameter.
(ii) It can reproduce complex conigurations other than simple
cylindrical structures, such as bifurcations.
(iii) It can reproduce a precritical original vascular structure from
a patient's damaged vascular structure (e.g., we can remove
aneurysms or widen an area of stenosis by computer).
Although maintaining a uniform thickness of the PLCL
membrane is dificult due to the limitations of dip coating, this
fabrication method has great potential to reconstruct tailor-
made biodegradable scaffolds based on CT images of vascular
structure. The relation between pore size and growth of
HUVECs (size: 10-60
μ
m) requires additional investigation.
8.7
Development of Biodegradable Scaffolds by
Casting from Magnetically Assembled Sugar
Particles
Recent progress in regenerative medicine is receiving attention as an
alternative treatment for organ transplantation. One main approach
to regenerating tissues is to reproduce an artiicial organ in vitro
irst and then transfer it into a patient's body [20, 21]. For in vitro
preparation of tissues, tissue engineering is very important in terms
of developing scaffolds that restore, maintain, and improve functions
of damaged tissue [22]. The development of appropriate 3D scaffolds
for the maintenance of cellular viability is important and has been a
challenge in the ield of tissue engineering. While scaffold materials
must meet certain biological criteria for implantation, an ideal
scaffold should have 3D well-connected macro and micro porous
structure to accommodate cells and to facilitate the transportation of
nutrient. In general, scaffolds with high porosity and interconnected
pores foster tissue regeneration as long as they have appropriate
strength.
 
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