Biomedical Engineering Reference
In-Depth Information
Table 3.1 Anti-GCPII antibodies described in the literature.
Antibody
Epitope
Reference
Applications
1,155
7E11-C5.3
Intracellular
(MWNLLH)
IP, IHC, WB
45
, Cornell
University
J591, J533, J415,
E99
Extracellular
Recognizes native
GCPII, IHC, IF, WB,
Elisa, imaging,
therapy
3C6
Extracellular
Northwest
biotherapeutics
156
Recognizes native
GCPII
1D11
Extracellular
Northwest
biotherapeutics
Recognizes native
GCPII
PEQ226.5
Extracellular
(region 134-437)
Hybritech Inc.
(San Diego, CA)
22
IHC, WB
PM2J004.5
Intracellular,
distinct from 7E11
Hybritech Inc.
(San Diego, CA)
22
Recognizes native
GCPII
157
3E11, 3C2,
4E10-1.14,3C9,
and 1G3
Differing regions of
the extracellular
domain
Recognizes native
GCPII
158
3F5.4G6
Extracellular, near
the C-terminus
WB
Y-PSMA-1
Extracellular
(716-723)
Abcam (ab19071),
Anogen
(MO-T40086A)
ELISA, IF, IHC, WB
Y-PSMA-2
Anogen
(MO-T40086B)
ELISA, IF, IHC, WB
159,160
107-1A4
Extracellular
IHC, IF, ELISA
161
24.4E6 (14.3C8,
58.3D3, 28.2E1)
extracellular
(638-657)
IHC
162
mAbs (3/E7,
3/F11, 3/A12)
Extracellular
Recognizes native
GCPII (ELISA)
162
scFv (A5)
Extracellular
Recognizes native
GCPII (ELISA)
73
GCP-01
GCP-01
WB
7,73
GCP-02
Extracellular
WB
7,73
GCP-04
Extracellular
(100-104)
WB, IHC,
immunofluorescence
163
, ProScan Rx
Pharma Inc
6 murine
antibodies
Extracellular (region
490-500)
Recognizes native
GCPII
87
, Progenics
Pharma Inc.
mAb 026
Dimer-specific
epitope
Recognizes native
GCPII
3.3.1 Protein Expression in Human and Animal Tissues
3.3.1.1 Human Tissues
GCPII expression has been repeatedly shown to be highest in prostate cancer
tissue. Nevertheless, varying amounts of GCPII have been described in both
normal and malignant tissues.
