Biomedical Engineering Reference
In-Depth Information
Figure 1.2
Schematic of the DP4-like gene family and related prolyl endopeptidase.
Domains and residues of interest are not arranged to scale. Arrows indi-
cate the catalytic residues required for enzyme activity. Only the main
isoforms are represented. The majority of splice variants differ in regard to
the length of their N-terminal cytoplasmic domain. Being intracellular
proteases, DP8, DP9, and PEP do not contain a transmembrane domain.
The integrin-binding domain of DP9 is also displayed within the N-
terminal cytoplasmic domain. Figure adapted from Gorrell.
61
Reproduced
with permission, from Gorrell (2005), Clinical Science, 108, 277-292.
r
The Biochemical Society. DP, dipeptidyl peptidase; FAP, fibroblast
activation protein; PEP, prolyl-endopeptidase.
serine residue of GWSYG.
7
Another distinguishing characteristic of the S9b
sub-family that differentiates them from PEP is the pair of conserved gluta-
mate residues situated within the b-propeller domain found to be essential for
