Biomedical Engineering Reference
In-Depth Information
thus attenuation of EGF receptor signaling, is a potential cancer therapy. On
the other hand, recovery from many diseases, wounds and chronic injuries
requires epithelial regeneration. Perhaps in vivo inhibition of DPP-9 enzyme
activity would promote Akt pathway activation and thus cell proliferation and
regeneration. These new data suggest that DPP-9 selective inhibitor develop-
ment is crucial to investigate potential applications.
5.5 Conclusion
The success and safety of targeting DPP-4 protease activity, as well as the
potential of FAP-specific proteolysis as a biomarker and therapeutic target,
depend upon a number of favorable biological and biochemical characteristics
of these unusual proteases. Additional therapeutic benefits of exploiting these
and related proteases are likely in future.
Acknowledgments
The authors acknowledge the National Health and Medical Research Council
of Australia for grants 512282 to MDG and 571408 to GWM. TWY and NAN
hold Australian Postgraduate Awards, and YC receives a University of Sydney
International Postgraduate Scholarship.
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