Biomedical Engineering Reference
In-Depth Information
The fifth step involves the reaction of succinyl
CoA, ADP, and
P
with the enzyme
succinyl
CoA synthetase, to create succinate,
and ATP
:
This reaction is given by
CoA
ð
8
:
108
Þ
The sixth step involves the reaction of succinate and
FAD
with the enzyme succinate
dehydrogenase to create fumarate and
FADH
2
. This reaction is given by
ð
8
:
109
Þ
The seventh step involves the reaction of fumarate and
H
O
with the enzyme fumarase
2
to create malate. This reaction is given by
ð
8
:
110
Þ
NAD
þ
with the enzyme malate dehy-
The last step involves the reaction of malate and
NADH
þ
H
þ
). This reaction is given by
drogenase to create oxaloacetate and (
ð
8
:
111
Þ
The final equation combines the oxaloacetate from the first reaction with that in the last
reaction:
q
O
¼
K
q
MTMTD
q
NAD
þ
K
8
q
O
q
MTD
q
NADH
þ
H
þ
B
q
O
ð
8
:
112
Þ
8
1
It should be clear that this reaction continually recycles and that it requires two cycles to
process each glucose molecule.
