Biomedical Engineering Reference
In-Depth Information
37
C Incubator
Chart Recorder
motor
magnetic stirrer
N
2
O
2
hole for probe
Insert
O-ring
FIGURE 6.30
Schematic diagram of the apparatus for measuring oxygen uptake rate.
From [14].
EXAMPLE PROBLEM 6.8
Oxygen can be delivered in situ over an oxygenation membrane, as illustrated in Figure 6.31.
At slow flow rates compared to the lateral diffusion rate of oxygen, the oxygen in the incoming
Oxygenation
Membrane
gas phase w/ controllable O
2
concentration
Fluid
Entering
w/ O
2
diffusing oxygen
Cell Bed
Surface
Conc. of
Oxygen
FIGURE 6.31
Oxygen delivery across a membrane that is placed on top of a fluid that is flowing across a
cell bed. If the fluid transit time is much slower than the diffusional time for oxygen, then oxygen is delivered
primarily via diffusion. This leads to a small entrance effect in which the oxygen in the incoming stream is
consumed, while the oxygen concentration over the rest of the cell bed is relatively constant.
Continued
