Biomedical Engineering Reference
In-Depth Information
a
TABLE 6.5
Components of the Extracellular Matrix
Component
Function
Location
Collagens
Tissue architecture, tensile strength
Ubiquitously distributed
Cell-matrix interactions
Matrix-matrix interactions
Elastin
Tissue architecture and elasticity
Tissues requiring elasticity (e.g., lung,
blood vessels, heart, skin)
Proteoglycans
Cell-matrix interactions
Ubiquitously distributed
Matrix-matrix interactions
Cell proliferation
Binding and storage of growth factors
Hyaluronan
Cell-matrix interactions
Ubiquitously distributed
Matrix-matrix interactions
Cell proliferation
Cell migration
Laminin
Basement membrane component
Basement membranes
Cell migration
Epiligrin
Basement membrane component (epithelium)
Basement membranes
Entactin (nidogen)
Basement membrane component
Basement membranes
Fibronectin
Tissue architecture
Ubiquitously distributed
Cell-matrix interactions
Matrix-matrix interactions
Cell proliferation
Cell migration
Opsonin
Vitronectin
Cell-matrix interactions
Blood
Matrix-matrix interactions
Sites of wound formation
Hemostasis
Fibrinogen
Cell proliferation
Blood
Cell migration
Sites of wound formation
Hemostasis
Fibrillin
Microfibrillar component of elastic fibers
Tissues requiring elasticity (e.g., lung,
blood vessels, heart, skin)
Continued
