Biomedical Engineering Reference
In-Depth Information
CHAPTER
6
Tissue Engineering
Randall E. McClelland, Robert Dennis, Lola M. Reid,
Jan P. Stegemann, Bernard Palsson, and Jeffrey M. Macdonald
OUTLINE
6.1 What Is Tissue Engineering?
274
6.6 Future Directions: Functional
Tissue Engineering and the
“-Omics” Sciences
6.2 Biological Considerations
290
347
6.3 Physical Considerations
319
6.7 Conclusions
349
6.4 Scaling Up
339
6.8 Exercises
349
6.5 Implementation of Tissue
Engineered Products
References
354
343
Suggested Readings
355
Glossary
356
AT THE CONCLUSION OF THIS CHAPTER, STUDENTS WILL BE
ABLE TO:
Discuss the growing area of cellular
therapies.
Discuss the three general categories of
extracorporeal bioreactors.
Understand the cellular dynamics
underlying tissue function.
Qualitatively describe the importance of
stem cells in tissue function.
Quantitatively describe cellular fate processes.
Analytically describe mass transfer in three
different configurations.
Explain the parameters that characterize
the tissue environment and how to approach
mimicking them in vitro.
Describe the issues fundamental to scale-up.
Define functional tissue engineering and
how the “-omics” sciences are driving this
newly created research area.
Discuss the issues that one encounters
when implementing cellular therapies
or bioartificial organs to patients.
