Biomedical Engineering Reference
In-Depth Information
CHAPTER 1
Nitric oxide (NO) electrochemical sensors
Xueji Zhang
1.1 Introduction
1.1.1 Signifi cance of nitric oxide in life science
1.1.2 Methods of measurement of nitric oxide in physiology
1.1.3 Advantages of electrochemical sensors for determination of NO
1.2 Principles of determination of NO by electrochemical sensors
1.3 Fabrication of electrodes for NO determination
1.3.1 Clark type NO electrodes
1.3.2 Modifi ed carbon fi ber NO microelectrodes
1.3.3 Integrated NO microelectrodes
1.3.4 Other NO electrodes
1.4 Calibration of NO electrodes
1.4.1 Calibration using an NO standard solution
1.4.2 Calibration based on decomposition of SNAP
1.4.3 Calibration based on chemical generation of NO
1.5 Characterization of NO electrodes
1.5.1 Sensitivity and detection limit
1.5.2 Selectivity
1.5.3 Response time
1.5.4 Effect of temperature and pH on NO electrodes
1.6 Selected applications of NO electrodes
1.7 Concluding remarks and other directions
1.8 Acknowledgments
1.9 References
1.1 INTRODUCTION
1.1.1 Signifi cance of nitric oxide in life science
Nitric oxide (NO) is reported to have been fi rst prepared by the Belgian scientist Jan
Baptist van Helmont in about 1620 [1]. The chemical properties of NO were fi rst
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