Detection of charged macromolecules by means of fi eld-effect devices (FEDs): possibilities and limitations - Electrochemical Sensors, Biosensors and Their Biomedical Applications - page 189

TABLE 7.1
(continued)

Hybridization

Sensor type Probe ssDNA; density Electrolyte Target cDNA Sensor signal time RE Ref.

p-channel Au-gate 12-mer thiol-modifi ed 12-mer cDNA ∆ V th 0.87 V several without RE [19]

(fl oating) FET; ssDNA, spacer; 3.5 minutes

10 8 molecules/cm 2 n-Si-SiO 2 (50 nm)

p-channel Au-gate 15-mer thiol-modifi ed phosphate buffer 15-mer cDNA ∆ V th 0.23 V Pt [22]

(fl oating) FET; ssDNA, spacer; 2.4 saline, pH 7.4

10 8 molecules/cm 2 n-Si-SiO 2 (50 nm)

Au-gate poly-Si thin 18-mer ssDNA, 5 mM phosphate 18-mer cDNA ∆ V th 355 mV 1 h 30 min Ag/AgCl [36]

10 12 10 13 fi lm transistor; buffer; pH 7.2 ∆ V fb 140 mV

ssDNA/cm 2 Au-gate MIS

capacitance
p-channel FET;

20-mer dsDNA; 2 0.01 mM KCl detection of 80 mV Ag/AgCl [16]

10 13 molecules/cm 2 1 mM

n-Si-SiO 2 (10 nm)- dsDNA 40 mV wire

poly-L-lysine 10 mM 10 mV

∆ V fb : fl at-band-voltage change; ∆ V th : threshold-voltage change; RE: reference electrode; APTES: 3-aminopropyltriethoxysilane.