Biomedical Engineering Reference
In-Depth Information
O
2
H
SOD (Cu(I))
O
2
H
2
O
2
O
2
SOD (Cu(II))
Homogeneous Catalytic O
2
•
Disproportionation
Heterogeneous Catalytic O
2
•
Disproportionation
Cathodic process
Anodic process
O
2
SOD (Cu(I))
e
SOD (Cu(I))
O
2
e
H
H
2
O
2
O
2
SOD (Cu(II))
SOD (Cu(II))
SCHEME 3
Schematic diagram illustrating the concept of the third-generation O
2
•
biosensors based on
the biocatalytic activity inherent in SODs toward the dismutation of O
2
•
. (Reprinted from [150], with per-
mission from the Royal Society of Chemistry.)
2
b
a
d
c
0
2
0.5
0
0.5
E
/ V vs Ag/AgCl
FIGURE 6.7
CVs obtained at (a, b) Cu,Zn-SOD/cysteine-modifi ed, (c) bare, and (d) cysteine-modifi ed
Au electrodes in 25 mM PBS (pH 7.4) saturated by N
2
(a, c, d) or O
2
(b). Solutions (b) and (c) contain
0.002 U ml
1
XOD and 25 mM xanthine. Potential scan rate, 100 mV s
1
. (Reprinted from [150], with per-
mission from the Royal Society of Chemistry.)
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