Interfacing Biomolecules, Cells and Tissues with Nanowire-based Electrical Devices - Applications of Electrochemistry and Nanotechnology in Biology and Medicine - page 67

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Interfacing Biomolecules, Cells and Tissues
with Nanowire-based Electrical Devices
Moria Kwiat and Fernando Patolsky
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-
Aviv University, Tel-Aviv 69978, Israel
I. INTRODUCTION
Detection and qualification of biological and chemical species are
critical to many areas of health care and the life sciences, from
diagnostic disease to the discovery and screening of new drug
molecules. Central to detection is the transduction of a signal asso-
ciated with the selective recognition of a species of interest. Sever-
al approaches have been reported for the detection of biological
molecules, including ELISA, 1 surface plasmon resonance, 2 nano-
particles, 3 chemically sensitive field-effect transistors 4 and micro-
cantilevers. 5 Although all have shown feasibility and promising
progress applicability, none has yet demonstrated the combination
of features required for rapid, highly sensitive multiplexed detec-
tion of biomolecules.
Nano-science and technology, whose unifying theme is the
control of matter in this size range, allows revolutionary changes
of the fundamental properties of matter and phenomena that are
often drastically different compared to those they exhibit on the