Electrochemical Analysis of Ion Channels and Transporters in Pore-Suspending Membranes - Applications of Electrochemistry and Nanotechnology in Biology and Medicine - page 311

A

8

I I ( ( t t ) )

R p R p

p p

off

PM

cis

4

nano-BLM

R m

0

on

-4

0 1 2 3 4 5

trans

t / s

125

B

off

100

75

cis

I ( t )
p R p

nano-BLM
+ bR

50

25

R el

0

on

-25

trans

0 1 2 3 4 5

t / s

Figure 17. A) Schematic drawing of the membrane setup as proposed for model A
together with simulated current traces based on model A using the following pa-
rameters: V * = 0.2 V, I p,0 = 10 -8 A, C m = 10 -8 F, C p = 10 -9 F. (—) G p = 10 -12 S, (---)
G p = 5·10 -9 S, (····) G p = 5·10 -8 S. B) Schematic drawing of the membrane setup as
proposed for model B together with simulated current trances based on model B
using the following parameters: V * = 0.2 V, I p,0 = 10 -8 A, C m = 10 -8 F, C p = 10 -9 F.
(—) G p = 10 -12 S, (---) G p = 5·10 -9 S, (····) G p = 5·10 -8 S.

§ ·

t

It () I I I exp (11)

¨ ¸

stat on,max stat

IJ

© ¹

on

with:

C

m

I I

(12)

on,max p,0

CC

mp