Biomedical Engineering Reference
In-Depth Information
Figure 14. (A) Representative current trace showing single pore fluc-
tuations induced by alamethicin. The nano-BLM was symmetrically
bathed in 0.5 M KCl and a holding potential of 70 mV was applied.
Data were filtered at 1 kHz. The whole burst of fluctuations is due to
a single pore event, fluctuating between conductance levels
O
1
-
O
5
.
O
1
= 16.4 pA;
O
2
= 79.1 pA;
O
3
= 171.7 pA;
O
4
= 281.6 pA;
O
5
= 415.2
pA.
C
= 3.0 pA reflects the current baseline with the channel closed.
(B) Corresponding current amplitude histogram. (Reprinted from Ref.
110
with kind permission from Elsevier.)
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