Biomedical Engineering Reference
In-Depth Information
3
Scanning Electrochemical Microscopy
Imaging of DNA Arrays for High
Throughput Analysis Applications
Koji Nakano
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744
Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
I. INTRODUCTION
With the completion of the human genome sequencing efforts,
functional genomics, which aims to understand the relationship
between an organism's genome and its phenotype, has become a
primary research field.
1
Various kinds of biochips, a bio-micro-
array device, are extensively used for substantial analysis purposes
by promoting the effective use of the vast wealth of data produced
by genomic projects.
2
The strength of biochips lies in the spatial
grid of miniaturized specific binding sites, at which unique binding
events can be analyzed simultaneously. Moreover, by introduction
into a microfluidic device, the next generation of biochips has been
found to possess both biochemical reaction capabilities, including
amplification, and chemical analysis. Such a device will be used
on a single platform with multiple reactions being carried out on
individual sites.
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