Biomedical Engineering Reference
In-Depth Information
Figure 7. (A) Schematic of the experimental approach. (a) NWFET chip, where NW devices are located at the central region of
the chip. The visible linear features (gold) correspond to NW contacts and interconnect metal. Zoom-in showing a source (S) and
2 drain (D) electrodes connected to a vertically oriented NW (blue arrow) define 2 NWFETs. (b) Cardiomyocytes cultured on thin
flexible pieces of PDMS, where one piece is being removed with tweezers (green). (c) PDMS substrate with cultured cells orient-
ed over the device region of the NWFET chip. The green needle-like structure indicates the probe used to both manipulate the
PDMS/cell substrate to specific NW device locations. (d) Schematic of a cardiomyocyte (black arrow) oriented over a NW (green
arrow) device. (e) Photograph of the experimental setup showing the PDMS piece (red dashed box) on top of a NWFET chip
within a solution well that is temperature-regulated with an integrated heater (blue arrow). Additional yellow, purple, green, and
red arrows highlight positions of the Ag/AgCl reference electrode, solution medium well, glass manipulator/force pipette connect-
ed to x - y - z manipulator, and plug-in connectors between NWFET interconnect wires and measurement electronics, respectively.
 
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