Biomedical Engineering Reference
In-Depth Information
TABLE 8.1
Summary of Parameter Combinations That Lead to a Controlled Remodeling
Process
Number of Parameters
in a Combination
Combinations of Differentiation and
Apoptosis Rates
Variation of Each
Parameter
2
D
OBP
/
A
OBA
+/+
2
D
OCP
/A
OST
+/-
2
A
OBP
/A
OCA
-/+
3
D
OBP
/
A
OBA
/
A
OCA
-/+/-
3
D
OBP
/
A
OBA
/
A
OCA
-/-/+
3
D
OBP
/
A
OBA
/
A
OST
+/-/+
3
A
OBA
/
A
OCA
/
A
OST
-/+/+
4
D
OBP
/
A
OCP
/
A
OBA
/
A
OCA
-/-/-/-
4
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
-/-/-/+
4
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
-/+/+/-
5
D
OBU
/
D
OBP
/
D
OCP
/
A
OBA
/
A
OST
+/-/-/+/-
5
D
OBU
/
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
-/+/-/+/-
5
D
OBP
/
D
OCP
/
D
OBA
/
A
OCA
/
A
OST
-/-/-/-/-
5
D
OBP
/
D
OCP
/
D
OBA
/
A
OCA
/
A
OST
+/-/-/+/-
Note:
Variations with “+” represent a parameter increase and those with “-“ represent a param-
eter decrease.
BV-90th day
100.20
100.15
100.10
100.05
100
-10
-5
0
5
10
Exponent
FIGURE 8.7
Typical physiologically realistic fluctuations of bone volume with combinations of parameter
change.
