Biomedical Engineering Reference
In-Depth Information
Having found a potential “ideal response curve,” we can begin a search
for response curves that might meet these requirements. Encouragingly, this
research is able to identify a small number of curves that possess similarity
to the idealized response curve. Table 7.3 summarizes all the parameter com-
binations that produce idealized response curves. Figure 7.8 illustrates the
TABLE 7.3
Summary of Parameter Combinations That Lead to Controlled Remodeling
Processes
Number of
Parameters in
a Combination
Variation of
Each Parameter
Combinations of Differentiation and Apoptosis rates
1
A
OBA
−
1
A
OST
−
2
D
OBP
/
A
OBA
+/−
2
D
OBP
/
A
OST
−/−
2
D
OCP
/
A
OBA
−/−
2
D
OCP
/
A
OST
−/−
2
A
OBA
/
A
OCA
−/+
2
A
OCA
/
A
OST
+/−
3
D
OBP
/
D
OCP
/
A
OBA
−/−/−
3
D
OBP
/
D
OCP
/
A
OBA
−/+/−
3
D
OBP
/
A
OBA
/
A
OCA
−/−/−
3
D
OBP
/
A
OBA
/
A
OCA
−/−/+
3
D
OBP
/
A
OBA
/
A
OST
−/−/−
3
D
OBP
/
A
OBA
/
A
OST
+/−/+
3
A
OBA
/
A
OCA
/
A
OST
−/+/+
4
D
OBU
/
D
OBP
/
A
OBA
/
A
OST
+/+/+/−
4
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
−/−/−/−
4
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
−/−/−/+
4
D
OBU
/
D
OCP
/
A
OBA
/
A
OST
−/+/−/−
4
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
−/−/+/−
4
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
+/−/−/+
5
D
OBU
/
D
OBP
/
D
OCP
/
A
OBA
/
A
OST
−/−/+/−/−
5
D
OBU
/
D
OBP
/
D
OCP
/
A
OBA
/
A
OST
+/−/−/+/−
5
D
OBU
/
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
−/+/−/−/−
5
D
OBU
/
D
OBP
/
A
OBA
/
A
OCA
/
A
OST
+/−/+/+/−
5
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
/
A
OST
−/+/−/−/−
5
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
/
A
OST
−/−/−/+/−
5
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
/
A
OST
−/−/−/−/+
6
D
OBU
/
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
/
A
OST
+/−/−/+/−/−
6
D
OBU
/
D
OBP
/
D
OCP
/
A
OBA
/
A
OCA
/
A
OST
+/−/−/+/+/−
Note:
The variation with “+” represents a parameter increase; “−” represents a parameter
decrease.
