Biomedical Engineering Reference
In-Depth Information
Experiment [58]
110
1*5
3*5
Experiment [58]
2*5
109
Present model
Present model
108
107
108
Experiment [58]
106
106
Present model
105
104
104
103
102
101
102
100
100
0
20
40
60
80
100
0
20
40
60
Time [days]
(b)
80
100
Time [days]
(a)
Simulation
Experiment
10
9
8
7
6
8
10
Time [weeks]
(c)
12
14
FIGURE 7.3
Simulation results of experiment in Saxon et al. [58]. (a): BMC (percentage) dynamics during
the loading period 15 weeks for 1 × 5 and 3 × 5 loading scheme. (b): BMC (percentage) dynam-
ics during the loading period 15 weeks for 2 × 5 loading scheme. (c): Trend comparison of
experiment and simulation results. In (a) and (b), the small squares and circles with the words
“Experiment [58]” and “Present model” represent the experimental and current simulation
results, respectively, on the 105th day.
In Figure  7.3(c), the three experimental results from Saxon et  al. [58] are
plotted and connected with solid line segments, and the three corresponding
simulation results are plotted and linked with dashed line segments. In a
model of this complexity, a close match of quantitative data is mostly based
on the careful choice of parameters. However, what is more important is
the ability of the model to predict the qualitative pattern of the response.
As can be seen from the graph, the trend of simulation is inconsistent with
the experiments. For the same reason, the focus in the following comparisons
is on the trends of changes (percentage of increase or decrease) rather than
 
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