Cortical Bone Remodeling under Mechanical Stimulus - Mechanics of Cellular Bone Remodeling - page 182

TABLE 7.1
Parameter Values and Description s

Symbol Unit Value Description

D OBU pM/day 7 × 10 −4 Differentiation rate of uncommitted OB progenitors

D OBP pM/day 5.348 Differentiation rate of preosteoblasts

D OCP pM/day 2.1 × 10 −3 Differentiation rate of preosteoclasts

A OBA pM/day 1.890 × 10 −1 Rate of elimination of OBA

A OCA pM/day 7.000 × 10 −1 Rate of elimination of OCA

A OST pM/day 3.1 × 10 −2 Rate of elimination of OST [20,21]

K D 1 ,T β pM 4.545 × 10 −3 Activation coefficient related to TGF-β binding on

OBU

K D 2 ,T β pM 1.416 × 10 −3 Repression coefficient related to TGF-β binding on

OBP

K D 3 ,T β pM 4.545 × 10 −3 Activation coefficient of TGF-β binding on OCA

K D 4 ,PTH pM 1.500 × 10 −2 Activation coefficient for RANKL eff on OBP related to

PTH binding

K D 7 ,PTH pM 2.226 × 10 −1 Repression coefficient for OPG production related to

PTH binding on OBA

K D 8 ,RL pM 1.500 × 10 −2 Activation coefficient related to RANKL binding on

OCP

K D 9 ,NO pM 1.573 × 10 Activation coefficient for OPG production on OBA

related to NO [20,21]

K D 10 ,NO pM 2.189 × 10 Repression coefficient for RANKL production on OBP

related to NO [20,21]

K D 11 ,P 2 pM 3.674 Activation coefficient for OBU differentiation related

to PGE 2 [20,21]

RK pM 1 × 10 Unchanged concentration of RANK

R RL — 3 × 10 6 Maximum RANKL on OBP

β PTH pM/cell 2.5 × 10 2 Synthesis rate of systemic PTH

β RL pM/cell 1.684 × 10 4 Production rate of RANKL per OBP

β OPG pM/cell 1.464 × 10 8 Production rate of OPG per OBA

D PTH

pM/day 8.6 × 10 Rate of degradation of PTH

D RL

pM/cell 1.013 × 10 Rate of degradation of RANKL

D OPG

pM/cell 3.5 × 10 −1 Rate of degradation of OPG

D T pM/cell 1 × 10 0 Rate of degradation of TGF-β

β

D NO

pM/cell 1 × 10 3 Rate of degradation of NO [20,21]

D P 2

pM/cell 1 × 10 2 Rate of degradation of T PGE 2 [20,21]

k T β — 0.5 Relative influence of TGF-β binding in OBU

differentiation

k P 2 — 0.5 Relative influence of PGE 2 in OBU differentiation

k PTH — 0.7 Relative influence of PTH binding in production of

OPG in OBA

k NO — 0.3 Relative influence of NO in production of OPG in OBA

K A 1, RL pM -1 1 × 10 −3 Association binding constant RANKL-OPG