Biomedical Engineering Reference
In-Depth Information
In.this.scanning.operation.the.resolution.improvement.factor.is.proportional.to.the.ratio.
between.the.scanned.region.and.the.diameter.of.the.probe,.
D
..If,.instead.of.super.resolu-
tion,. one. wishes. to. increase. the. imaging. ield. of. view,. the. probe. needs. to. be. shifted. at.
amplitude.of.less.than.
d
.to.generate.over-sampling.of.the.spectrum.domain.by.its.multiple.
cores..In.this.case,.a.set.of.images.are.captured.and.each.is.obtained.after.performing.a.shift.
of.sub-core.distance..Then,.all.the.images.are.interlaced.together.accordingly.to.generate.
effective.sub-core.sampling.
In. the. case. of. near. ield. approximation,. temporal. scanning. once. again. can. improve. the.
resolving.capability.as.described.in.literatures.(Fortin.et.al..1994,.Borkowski.et.al..2009)..In.
this.case.the.shift.is.limited.by.the.size.of.
d
..Once.again,.a.set.of.images.is.captured.while.
each.image.is.obtained.after.performing.a.shift.of.sub-core.distance..Then,.all.the.images.are.
interlaced.together.accordingly.to.generate.effective.sub-core.sampling..If.instead.of.resolu-
tion.improvement,.one.wishes.to.obtain.an.increase.in.the.imaging.ield.of.view,.the.probe.
can.again.perform.scanning.but.this.time.at.larger.amplitude..The.ield.of.view.enlargement.
is.proportional.to.the.ratio.between.the.shift.amplitude.and.the.diameter.of.the.probe.
D
.
26.4 Conclusions and Perspectives
In.this.chapter.we.have.presented.a.new.type.of.multifunctional.micro.probe.with.a.sub-
millimeter.diameter..The.sub-millimeter.diameter.of.the.proposed.micro.probe.makes.it.
suitable.to.perform.non-invasive.medical.treatments,.such.as.going.into.veins.and.other.
internal. organs.. The. combination. of. its. sub-millimeter. diameter. and. its. multifunctional.
capabilities.allows.realization.of.localized.bio.medical.inspection.as.well.as.treatment.
In. the. capabilities. demonstrated. in. this. chapter. we. showed. preliminary. results. of. a.
micro.probe.with.a.diameter.of.100-200.μm,.which.produced.images.of.5,000-10,000.pixels.
before.applying.super.resolving.techniques..After.using.super.resolution,.the.obtainable.
resolution.limit.and.the.ield.of.view.improved.and.exceeded.the.state-of-the-art.resolu-
tion.and.ield.of.view.available.nowadays.from.conventional.endoscopes.
Experimental. results. showing. the. construction. of. various. resolution. targets. as. well. as.
different. biological. tissues. have. been. presented.. We. believe. that. generating. a. one-piece.
tool.that.enables.not.only.monitoring.of.internal.organs.but.also.treatment.using.the.same.
probe. will. improve. the. medical. examination. procedure. from. both. the. doctor's. and. the.
patient's. point. of. view.. In. addition,. the. micro. probe. can. not. only. be. integrated. in. any.
existing.endoscopy.examination,.but.also.can.also.open.a.window.for.new.medical.exami-
nation. that. is. still. not. reachable. due. to. the. relatively. large. size. of. the. currently. existing.
endoscopes.compared.to.the.suggested.one.
Acknowledgment
The.authors.would.like.to.acknowledge.the.inancial.support.given.to.this.research.from.
NIH.grant.R21.5R21EB009138-02.entitled.“Novel.nano-pipette.for.imaging.of.deep.cortical.
layers.and.deep.brain.structures.”.Zeev.Zalevsky.would.like.to.acknowledge.the.inancial.
support.given.by.Leon.and.Maria.Taubenblatt.Prize.for.Excellence.in.Medical.Research.
