Biomedical Engineering Reference
In-Depth Information
TABLe 20.4
Inluence.of.Nanoscale.Features.on.Cellular.Function
Depth/
Height
Topography
Study
Cell Type
Chemistry
Width
Pitch
Functional Modiication
Sjostrom.et.al..(2009)
Human.mesenchymal.
stem.cells
Ti
40.nm
28.nm
15.nm
Upregulation.of.osteospeciic.
markers
Nanoscale.
protrusions
Pezzatini.et.al..(2007)
Bovine.postcapillary.
venular.endothelial.cells
Hydroxyapatite
200.nm
Variable
40.nm
Increased.synthesis.of.
ibroblast.growth.factor
Pan.et.al..(2012)
Rat.embryonic.
cardiomyoblast
Tantalum.oxide
110.nm
100.nm
100.nm
Upregulation.of.genes.
associated.with.
ibrosis—Hsp90
Migliorini.et.al..
(2011)
Mouse.neuroprogenitor.
cells
Poly(dimethylsiloxane)
250
500
360
Increased.neuron.
differentiation—TAU.
expression
Park.et.al..(2009)
Rat.hematopoietic.stem.
cells
TiO
2
15.nm
15.nm
1.5.μm
Upregulation.of.osteospeciic.
markers
Nanoscale.
pits
Dalby.et.al..(2007)
Human.osteoprogenitor.
cells
Poly(methyl.methacrylate)
120.nm
300.nm
100
Upregulation.of.osteospeciic.
markers
Lim.et.al..(2007)
Human.fetal.osteoblastic
Poly(l-lactic.acid)/
poly(styrene).blend
500.nm
Variable
29.nm
Increase.in.FAK.
phosphorylation
Ferraz.et.al..(2011)
In.vivo.mouse.
phagocytes
Aluminum.oxide
200.nm
Variable
Pores
Increased.inlammatory.
response
Biggs.et.al..(2009a,b)
Human.osteoprogenitor.
cells
Poly(methyl.methacrylate)
1000.nm
1000.nm
330.nm
Upregulation.of.ERK.
signaling.pathways
Nanoscale.
grooves
Yim.et.al..(2007)
Human.mesenchymal.
stem.cells
Poly(dimethylsiloxane)
350.nm
700.nm
350.nm
Upregulation.of.neuronal.
markers—MAP2.and.GFAP
Jin.et.al..(2008)
Canine.kidney.cells
Poly(styrene)
350.nm
350
40.nm
Upregulation.of.cyclin.D1.and.
keratin.18
Lamers.et.al..(2011)
Rat.macrophage.cells
Poly(styrene)
77.nm
150.nm
32.nm
Upregulation.of.inlammatory.
cytokines—IL-1β.and.TNF-α
Nanotopographical.modiication.induces.functional.changes.in.a.wide.variety.of.cell.types..Nanoprotrusions.have.shown.to.upregulate.the.synthesis.of.endothelial,.
cardio.neural,.and.osteospeciic.proteins.in.vitro..Nanoscale.pits.have.been.shown.experimentally.to.induce.osteospeciic.function.and.FAK.signaling.in.progenitor.
cell.populations.as.well.as.an.enhanced.inlammatory.response.in.mouse.phagocytes.cells..Nanogrooves.have.been.shown.to.induce.neurospeciic.differentiation.
in.mesenchymal.stem.cells.(GFAP,.glial.ibrillary.acidic.protein;.MAP2,.mitogen-activated.protein.2),.and.the.upregulation.of.proteins.concerned.with.proliferation,.
differentiation,.and.the.inlammatory.response.
