Biomedical Engineering Reference
In-Depth Information
1.6.8 Nanoelectronic and Nanophotonic Applications
DNA.nanostructures.could.be.very.useful.as.structural.templates.for.functional.electronic.
or. photonic. components.. An. M13. mp18. DNA. rectangle. was. labeled. with. luorescent.
dyes. in. speciic. locations. (e.g.,. opposite. corners. separated. by. 89.5.nm);. the. dyes. were.
introduced.as.5′.labels.on.two.staple.strands..79%.of.the.observed.origami.contained.two.
dyes..Super-resolution.imaging.techniques.(Blink.microscopy,.SHRImP,.and.dSTORM).
all.resolved.the.two.dyes.and.showed.the.expected.separations.(Steinhauer.et.al..2009)..
The. capabilities. of. DNA. origami. for. structural. organization. of. non-DNA. components.
are.being.used.to.construct.nanophotonic.devices,.which.require.that.nanoparticles.of.
different.sizes.or.materials.be.placed.in.speciic.locations..Ding.et.al..(2010a).(Figure.1.13).
showed. that. 15,. 10,. and. 5.nm. gold. nanoparticles. could. be. recruited. on. a. single. side.
of. a. DNA. origami. triangle.. Later. work. has. expanded. this. project. to. include. other.
nanoparticles,. nanostructures,. and. optical. measurements. on. the. resulting. photonic.
structures.(Pal.et.al..2011)..Yields.are.still.a.problem.for.these.derivatizations..Providing.
several.nearby.binding.sites.can.increase.the.fraction.of.origami.that.successfully.capture.
a.nanoparticle.
DNA. nanostructures. can. also. be. directly. metallized. (He. et. al.. 2011).. Metallization. by.
electroless.deposition.or.by.thermal.evaporation.gives.preferential.metal.deposition.on.the.
DNA,.leading.to.conductive.nanowires,.although.often.the.metallic.wires.are.signiicantly.
wider.than.the.DNA.template.(Lund.et.al..2006,.Park.et.al..2006b)..More.complex.nanoelec-
tronic.devices.have.also.been.constructed..By.attaching.lines.of.ss.DNA.with.an.afinity.
for.carbon.nanotube.surfaces.atop.a.DNA.origami,.carbon.nanotubes.could.be.attached.to.
+
200 nm
(a)
(b)
Figure 1.13
(See companion CD for color igure.)
.(a).Schematic.shows.design.of.triangular.DNA.origami.with.adhesion.
sites.to.bind.six.different.nanoparticles..(b).Electron.micrograph.shows.assembly.of.photonic.structure.on.DNA.
triangles..The.metal.nanoparticles.appear.as.bright.dots..Inset.shows.enlarged.image..(Reprinted.with.permis-
sion.from.Ding,.B..et.al.,.and.Yan,.H.,.Interconnecting.gold.Islands.with.DNA.origami.nanotubes,.
Nano Lett
.,.10,.
5065-5069..Copyright.2010b.American.Chemical.Society.)
