Biomedical Engineering Reference
In-Depth Information
(a)
(b)
(c)
270°
90°
0°
0°
90°
0°
Chamber
180°
270°
180°
270°
280°
90°
(d)
(e)
(f )
Figure 17.5
(See companion CD for color igure.)
.Quadruple.electrode.conigurations..(a).Polynomial..(Reproduced.with.
kind. permission. from. Springer. Science+Business. Media:.
BioMEMS Biomed. Nanotechnol
.,. Dielectrophoretic.
traps. for. cell. manipulation,. 4,. 2007,. 159-186,. Voldman,. J.,. Springer,. E.D.,. Ferrari,. M.S.,. Bashir,. R.,. and.
Wereley,. S.,. Copyright. 2007.). (b). Planar.. (Reprinted. from.
Biosens. Bioelectron.,
. 20,. Zheng,. L.,. Brody,. J.P.,. and.
Burke,.P.J.,.Electronic.manipulation.of.DNA,.proteins,.and.nanoparticles.for.potential.circuit.assembly,.606-619..
Copyright. 2004,. with. permission. from. Elsevier.). (c). Extruded. quadruple. electrodes. for. static. DEP. trapping..
(Reprinted.from.
J. Electrostat.,
.57,.Voldman,.J.,.Toner,.M.,.Gray,.M.L.,.and.Schmidt,.M.A.,.Design.and.analysis.
of. extruded. quadrupolar. dielectrophoretic. traps,. 69-90.. Copyright. 2003,. with. permission. from. Elsevier.). (d).
Polynomial,.(e).square.spiral,.and.(f).circular.electrodes.for.ROT.and.TWD.
its.lexibility.for.electrode.scaling.up.at.different.levels..As.shown.in.Figure.17.4a,.typical.
castellated.electrodes.consist.of.two.arrays.of.parallel.electrodes.with.one.electrode.array.
deeply.protruded.in.the.gaps.of.the.other..The.distances.between.the.adjacent.electrodes.
are.often.comparable.to.the.width.of.each.electrode.(varying.from.10.to.100.μm.usually).
and.the.optimal.dimensions.are.determined.by.the.size.of.the.targeted.particles..The.classic.
castellation. design. can. also. be. extended. to. 2D. (Figure. 17.4b). or. two-layer. (Figure. 17.4c).
formats.. The. 2D. design. (often. called. interdigitated. castellation. electrodes). comprises.
a. secondary. comb. structure. on. each. foot. of. the. major. comb,. orienting. perpendicularly..
This.design.is.widely.adopted.in.static.DEP.particle.trapping.and.separation.based.on.the.
different. p-DEP. and. n-DEP. motions. of. particles. in. a. mixture.. The. two-layer. castellation.
coniguration. forms. a. so-called. railway. track. pattern. and. is. often. seen. in. particle.
manipulations.(ROT.and.linear.transportation).by.TWD..Because.of.the.potential.electric.
circuit. crossing. issues,. more. complicated. microfabrication. and. integration. processes. are.
usually. required. in. the. fabrication. of. these. electrodes.. Recently,. a. concentric. design. has.
been.proposed.for.the.convenience.of.interdigitated.electrode.scaling.up.(Manaresi.et.al..
2003;.Narayanan.et.al..2006)..It.has.a.CMOS-like.electrode.coniguration.(CMOS.stands.for.
