Biomedical Engineering Reference
In-Depth Information
TABLe 14.6
Examples.of.Electrospun.Nanoibers.in.Drug.Delivery.Systems
Electrospinning
Modes
Delivered
Agents
Type
Polymers
Major Results
References
Proteins
Poly(vinyl.
alcohol),.PVA
Metal.frame.
collector
Solvent:.Water
12.cm.(distance)
55.kV.(voltage)
FITC-Bovine.
serum.albumin.
(FITC-BSA)
Release.of.FITC-BSA.
from.the.nanoibers
Zeng.et.al..
(2005)
Growth.
factors
PCL.and.ethyl.
ethylene.
phosphate.
(PCLEEP)
Solvents:.
Dichloromethane.
5-10.cm
20.kV
9.0.mL/min
β-Nerve.growth.
factor.(NGF)
Sustained.release.of.
bioactive.NGF.for.
3.months
Chew.et.al..
(2005)
Enzymes
Poly(dl-lactic.
acid),.PDLLA.
along.with.
methyl.
cellulose.(MC)
Emulsion.
electrospinning
Solvents:.
chloroform
15.cm
15-30.kV
3.6-5.4.mL/h
Lysozyme
Release.of.proteins.at.
a.constant.rate.for.
several.days.after.
initial.burst.release
Yang.et.al..
(2007)
Anticancer.
drugs
PEO.and.
chitosan.with.
hyaluronic.
acid.surface.
modiication
Rotating.
aluminum.shaft.
collector
12-20.kV
0.3.mL/h
Paclitaxel
Decreased.number.of.
prostate.cancer.cells.
on.the.ibers.with.
increasing.
concentration.of.
paclitaxel.loading
Ma.et.al..
(2011)
Anti-
infection.
drugs
PEVA,.PLA,.
and.a.blend.of.
the.two
Aligned.1-6.μm
Tetracycline.
hydrochloride
Steadily.released.the.
drug.over.5.days
Kenawy.
et.al..
(2002)
For.example,.electrospun.mats.are.of.great.interest.to.anticancer.drug.loading.because.of.
their.ability.to.protect.the.drug.and.preserve.its.function.(Sill.and.von.Recum.2008,.Park.
et.al..2010)..This.is.imperative.to.directly.target.the.tumors.because.drugs.in.free.form.
often.lose.anticancer.activity.after.a.certain.period.of.time..Xu.et.al..(2006).conducted.a.
speciic.example.of.this.in.a.study.involving.the.anticancer.drug.bis-chloronitrosourea.
(BCNU).. To. be. brief,. the. drug. was. loaded. into. a. PEG-PLLA. nanoibrous. mat. and. its.
release.was.observed.on.rat.Glioma.C6.cells..They.concluded.that.unloaded.ibers.had.no.
effect.on.cell.growth.and.that.those.loaded.with.the.anticancer.drug.exhibited.anticancer.
activity.over.a.72.h.period..In.addition,.they.tested.free.BCNU.on.the.same.tumor.cells.
and. noticed. it. began. to. lose. its. anticancer. activity. after. 48.h.. This. is. just. one. example.
with.a.nanoibrous.scaffold..Recent.studies.have.shown.potential.for.nanoparticles.to.be.
encapsulated.in.electrospun.nanoibers.in.order.for.programmable.release.of.dual.drugs.
(Wang.et.al..2011).
An.example.of.this.would.be.small.insoluble.particles.added.to.the.solution.that.become.
encapsulated.in.the.nanoibers.(Huang.et.al..2003,.Angammana.and.Jayaram.2011)..Small.
particles.could.refer.to.soluble.drugs,.bacterial.agents,.and.even.nanoparticle.suspensions..
For.example,.hydroxyapatite.nanoparticle.suspensions.have.been.incorporated.into.poly-
ɛ-caprolactone/poly-l-lactic. acid. nanoibers. in. order. to. advance. bone. regeneration. tech-
niques.(Bakhshandeh.et.al..2011)..Thus,.the.beneit.of.small.particle.incorporation.could.be.
for.therapeutic.or.diagnostic.purposes.
