Biomedical Engineering Reference
In-Depth Information
TABLe 14.5
Examples.of.Electrospun.Nanoibers.in.Tissue.Engineering
Purpose
Polymers
Fiber Diameters
Cell Types
Results
References
Wound.
healing
Silk.
ibroin.
(SF)
30-120.nm
Normal.human.
keratinocytes.
and.ibroblasts
Promoted.cell.
adhesion.and.
spreading.of.type.I.
collagen
Min.et.al..
(2004)
Neural.repair
PLLA
Aligned:.150-
500.nm.for.2%.
and.800-3000.nm.
for.5%.solutions
Random:.700.nm.
for.2%.and.3.5.μm.
for.5%.solutions
Neonatal.mouse.
cerebellum.
C17.2.stem.cells.
(NSC)
Aligned.nanoibers.
supported.NSC.
culture.and.
improved.neurite.
outgrowth
Yang.et.al..
(2005)
Bone.
regeneration
PCL
20.nm-5.μm
Mesenchymal.
stem.cells.
(MSCs)
Mineralized.tissue.
formation
Yoshimoto.
et.al..
(2002)
Vascular.
tissue.
engineering
PLLA
0.5-1.μm
Smooth.muscle.
cells,.bone.
marrow.
mesenchymal.
stem.cells
Remodeled.vascular.
grafts.in.ECM.and.
cellular.content;
Similar.structure.to.
that.of.the.native.
artery
Hashi.et.al..
(2007)
Adipose.
tissue.
engineering
PCL
691.nm
Murine.
embryonic.stem.
cells.(mESCs)
Functional.3D.
adipose.tissue.
formation
Kang.et.al..
(2007)
Eye.tissue.
engineering
Poly(ester.
urethane).
urea.
(PEUU)
165.±.55.nm
Human.corneal.
stromal.stem.
cells.(hCSSCs)
Aligned.nanoibers.
for.hCSSCs.
secreted.type-I-
collagen-based.
ECM,.which.
structurally.
resembled.
characteristics.of.
native.human.
cornea.stromal.
tissue
Wu.et.al..
(2012)
observing.the.diameter.change.within.the.physiological.pressure.range..The.change.was.
about.9%.for.native.vessels.and.approximately.12%-14%.for.electrospun.scaffolds.(Stitzel.
et.al..2006)..Additionally,.silk.ibroin.extracted.from.
Bombyx mori
.(silkmoth).has.also.been.
proven.to.be.an.extremely.versatile.biocompatible.and.biodegradable.material..It.has.the.
potential.to.be.used.as.a.biomaterial.for.implants,.scaffolding,.disease.models,.and.drug.
delivery.(Rockwood.et.al..2011).
In.terms.of.synthetic.materials,.there.is.a.subdivision.of.biodegradable.and.nondegradable.
materials.. The. attraction. to. biodegradable. materials. is. that. they. result. in. a. less. invasive.
approach. where. surgery. is. not. necessary. to. remove. the. implanted. scaffold.. There. is.
also. allure. toward. the. ability. to. control. the. rate. of. degradation. in. parallel. to. the. rate. of.
new.tissue.formation.(Thomson.et.al..1995,.Holy.et.al..2000,.Shin.et.al..2003)..This.can.be.
accomplished.by.altering.polymer.blends.and.the.ratio.of.amorphous.to.crystalline.portions.
(Sill.and.von.Recum.2008)..Examples.of.biodegradable.synthetic.materials.would.include.
polyesterurethane,. PLGA,. and. PLA. (poly. lactic. acid).. Studies. examining. nondegradable.
