Biomedical Engineering Reference
In-Depth Information
proteins.(FPR-Rs),.involved.in.the.sensing.of.chemicals.associated.with.pathogens.(Riviere.
et.al..2009,.Nilius.and.Appendino.2011).
It.is.assumed.that.each.odorant/volatile.requires.a.particular.set.of.ORs.to.send.a.speciic.
recognition. signature. to. the. brain.. Overlapping. ligand. afinities. between. ORs. allows.
us. to. identify. complex. mixtures. of. odorants. and. interpret. these. as. a. particular. smell.
signature..The.ultimate.goal.will.be.to.decipher.these.recognition.signatures..Using.ORs.in.
combinatorial,.multiplex.arrays.will.allow.us.to.map.and.record.complex.odorant.mixtures..
This. will. facilitate. the. need. to. establish. odorant. libraries. of. digital. odorant. signature.
maps.. Besides. using. this. information. for. design. of. speciic. OR. biosensor. applications,.
this.knowledge.will.be.invaluable. in.the.identiication.of.ligands.for.the.majority.of.OR.
proteins.that.still.remain.classiied.as.orphan.receptors.
References
Alinito,. E.,. Pennetta,. C.,. and. Reggiani,. L.. 2010.. Olfactory. receptor-based. smell. nanobiosensors:.
An.overview.of.theoretical.and.experimental.results.. Sensors and Actuators B ,.146,.554-558.
Anker,.J..N.,.Hall,.W..P.,.Lyandres,.O.,.Shah,.N..C.,.Zhao,.J.,.and.Van.Duyne,.R..P..2008..Biosensing.
with.plasmonic.nanosensors.. Nature Materials ,.7,.442-453.
Bayburt,.T..H..and.Sligar,.S..G..2010..Membrane.protein.assembly.into.Nanodiscs.. FEBS Letters ,.584,.
1721-1727.
Besteman,.K.,.Lee,.J.-O.,.Wiertz,.F..G..M.,.Heering,.H..A.,.and.Dekker,.C..2003..Enzyme-coated.carbon.
nanotubes.as.single-molecule.biosensors.. Nano Letters ,.3,.727-730.
Buck,. L.. and.Axel,. R.. 1991..A. novel. multigene. family. may. encode. odorant. receptors:.A. molecular.
basis.for.odor.recognition.. Cell ,.65,.175-187.
Castellana,.E..T..and.Cremer,.P..S..2006..Solid.supported.lipid.bilayers:.From.biophysical.studies.to.
sensor.design.. Surface Science Reports ,.61,.429-444.
Chen,. R.. J.,. Bangsaruntip,. S.,. Drouvalakis,. K..A.,. Kam,. N.. W.,. Shim,. M.,. Li,.Y.,. Kim,. W.,. Utz,. P.. J.,.
and.Dai,.H..2003..Noncovalent.functionalization.of.carbon.nanotubes.for.highly.speciic.elec-
tronic.biosensors.. Proceedings of National Academy of Sciences of the United States of America ,.100,.
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Chung,.T.,.Lee,.S..Y.,.Song,.E..Y.,.Chun,.H.,.and.Lee,.B..2011..Plasmonic.nanostructures.for.nano-scale.
bio-sensing.. Sensors (Basel) ,.11,.10907-10929.
Cook,. B.. L.,. Ernberg,. K.. E.,. Chung,. H.,. and. Zhang,. S.. 2008.. Study. of. a. synthetic. human. olfactory.
receptor.17-4:.Expression.and.puriication.from.an.inducible.mammalian.cell.line.. PLoS ONE ,.
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Cook,.B..L.,.Steuerwald,.D.,.Kaiser,.L.,.Graveland-Bikker,.J.,.Vanberghem,.M.,.Berke,.A..P.,.Herlihy,.
K.,.Pick,.H.,.Vogel,.H.,.and.Zhang,.S..2009..Large-scale.production.and.study.of.a.synthetic.G.
protein-coupled. receptor:. Human. olfactory. receptor. 17-4.. Proceedings of National Academy of
Sciences of the United States of America ,.106,.11925-11930.
Covington,. J.. A.,. Gardner,. J.. W.,. Hamilton,. A.,. Pearce,. T.. C.,. and. Tan,. S.. L.. 2007.. Towards. a. truly.
biomimetic.olfactory.microsystem:.An.artiicial.olfactory.mucosa.. IET Nanobiotechnology ,.1,.15-21.
Dodevski,. I.. and. Plückthun,.A.. 2011.. Evolution. of. three. human. GPCRs. for. higher. expression. and.
stability.. Journal of Molecular Biology ,.408,.599-615.
Ferreira,. G.. N.. M.,. Da-Silva,.A.-C.,. and. Tomé,. B.. 2009..Acoustic. wave. biosensors:. Physical. mod-
els. and. biological. applications. of. quartz. crystal. microbalance.. Trends in Biotechnology ,. 27,.
689-697.
Fromherz,.P.,.Offenhausser,.A.,.Vetter,.T.,.and.Weis,.J..1991..A.neuron-silicon.junction:.A.Retzius.cell.
of.the.leech.on.an.insulated-gate.ield-effect.transistor.. Science ,.252,.1290-1293.
 
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