Biomedical Engineering Reference
In-Depth Information
Writing direction
0
μm
5
(a)
Ion beam
Particle extraction
(b)
Selective electron beam exposure
(c)
500 nm
Master mold
Resist
Substrate
Etching
Replica of master mold
(d)
Figure 8.3
(See companion CD for color igure.)
.Various.techniques.used.to.generate.ordered.nanotopography.on.a.sub-
strate.of.interest..(a).Dip-pen.nanolithography.involves.deposition.of.“ink”.molecules.onto.a.surface.using.an.
AFM.tip..(Reprinted.with.permission.from.Piner,.R.D..et.al.,.
Science
,.283(5402),.661,.1999.).(b).Colloidal.lithogra-
phy.employs.self-assembling.nanoparticles..When.subject.to.an.ion.beam,.nanopillars.are.produced..With.ilm.
evaporation,.particle.removal.results.in.a.surface.dotted.with.nanopits..(Reprinted.with.permission.from.Wood,.
M..et.al.,.
Nanotechnology
,.13(5),.605,.2002.).(c).Electron.beam.lithography.transfers.a.wide.range.of.nanopatterns.
onto.substrates.with.the.aid.of.resists..(Reprinted.with.permission.from.Curtis,.A.S.G..et.al.,.
J. R. Soc. Interface
,.
3(8),. 393,. 2006.). (d). Nanoimprint. lithography. requires. stamping. with. a. master. mold. and. subsequent. etching..
(Reprinted.from.
Biomaterials
,.26(26),.Yim,.E.K.F.,.R.M..Reano,.S.W..Pang.et.al.,.Nanopattern-induced.changes.in.
morphology.and.motility.of.smooth.muscle.cells,.5405-5413,.Copyright.2005,.with.permission.from.Elsevier.)
