Biomedical Engineering Reference
In-Depth Information
Syringe
Collector
Power source
(a)
Heating and/or freezing
Removal of polymer
poor fraction
(b)
Hydrophilic
head
Hydrophobic
tail
200 nm
(c)
Figure 8.2
(See companion CD for color igure.)
.Scaffolds.comprising.ibers.or.macroporous.structure.present.unordered.
topography..Several.processing.techniques.include:.(a).Electrospinning,.where.a.liqueied.polymer.subjected.
to. high. voltage. is. coaxed. through. a. capillary. needle. onto. a. collector. plate. to. produce. long,. thin. nanoibers..
(Venugopal,. J.. et. al.,. Biomimetic. hydroxyapatite-containing. composite. nanoibrous. substrates. for. bone. tissue.
engineering,.
Philos. Trans. R. Soc. A Math. Phys. Eng. Sci
.,.368(1917),.2065-2081,.2010..Reprinted.by.permission.of.
Royal.Society.Publishing.).(b).Thermally.induced.phase.separation,.in.which.a.porous.structure.is.created.from.
a.polymer-rich.fraction.obtained.through.changes.in.temperature..(Reprinted.with.permission.from.Spadaccio,.
C.. et. al.,.
Front. Biosci
.,. 3(Suppl),. 901,. 2011.). (c). Self-assembly. of. peptide. amphiphiles,. entailing. spotaneous.
molecular. aggregation. to. generate. a. nanoibrous. network.. (Reprinted. with. permission. from. Hartgerink,. J.D..
et.al.,.
Science
,.294(5547),.1684,.2001.)
Emphasis. on. biomimetic. material. usage. resulted. in. the. creation. of. co-spun. gelatin,.
elastin,. and. poly(lactide-
co
-glycolide). (PLGA). scaffolds—the. latter. providing. structural.
support.to.the.former.two.inherently.weak.ECM.matrix.components..These.biocompatible.
products. were. successful. in. facilitating. the. organotypic. distribution. of. both. human.
epithelial.and.bovine.smooth.muscle.cells.(Han.et.al..2010).
A.collagen.I-blended.PLGA.nanoibrous.scaffold.received.a.surface.coating.of.endothelial.
leukocyte.adhesion.molecule-1.(E-selectin)—a.functional.ligand.for.bone.marrow-derived.
