Virus-Based Nanobiotechnology - The Nanobiotechnology - page 168

Disk

Single helix

+ Genomic
DNA

Figure 7.11
TMV. capsomer. undergoes. a. conformational. change. upon. interaction.
with. DNA.. (Klug,. A.,. The. tobacco. mosaic. virus. particle:. Structure. and.
assembly,. Philos. Trans. R. Soc. Lond. B: Biol. Sci .,.1999,.354(1383),.531-535..
Adapted.by.permission.of.The.Royal.Society.of.Chemistry.)

'Lock-washer'

of. inorganic. materials. being. nucleated. on. the. surface. of. TMV. was. in. 1999.. In. this.
groundbreaking. study,. pH-dependent. nucleation. of. nanoclusters. of. iron. oxides,. silicon.
dioxide,.lead.sulide,.and.cadmium.sulide.on.the.exterior.of.the.native.TMV.capsid.were.
demonstrated. (Shenton. et. al.. 1999).. Investigations. into. other. material. systems. and. their.
ability.to.be.biotemplated.on.TMV.rapidly.followed..Realization.that.the.central.channel.
of.TMV.could.be.activated.by.treatment.with.palladium.or.platinum.precursors.enabled.
site-speciic.deposition.of.metals.to.form.high-aspect.ratio.nanowires..As.can.be.seen.in.
Figure. 7.12,. precursor. nucleation. followed. by. electroless. deposition. of. either. cobalt. or.
nickel,. afford. 3.nm. diameter. nanowires. up. to. 500.nm. in. length,. spanning. the. channels.
of. two. virions. (Knez. et. al.. 2003).. The. following. work. involved. expanding. the. material.
set. further,. nucleating. gold. nanoclusters. on. the. exterior. and. interior. of. native. virions.
(Knez.et.al..2004)..An.alternative.approach.for.using.TMV.as.a.material.template.has.been.

100 nm

100 nm 100 nm

(a) (b)

Figure 7.12
Nickel.(a).and.cobalt.(b).nanowires.deposited.in.the.interior.channel.of.TMV.after.activation.with.palladium..
(Reprinted. with. permission. from. Knez,. M.,. Bittner,. A.M.,. Boes,. F.,. Wege,. C.,. Jeske,. H.,. Maiß,. E.,. Kern,. K.,.
Biotemplate.synthesis.of.3-nm.nickel.and.cobalt.nanowires,. Nano Lett .,.3(8),.1079-1082..Copyright.2003.American.
Chemical.Society.)