DNA Damage Response Research, Inherent and Future Nano-Based Interfaces for Personalized Medicine - The Nanobiotechnology - page 138

Environmental

ROS

H 2 O 2

NP

SWCNT Au-NP ISFET

Personalized nanomedicine

Figure 6.3
(See companion CD for color igure.) .Cellular.DNA.is.under.constant.mutagenic.attack.from.environmental.
agents.and.ROS.generated. in vivo ..Advances.in.nanomedicine.using.single-walled.carbon.nanotubes.(SWCNT).
have.made.it.possible.to.detect.ROS.on.an.individual.cell.scale..Direct.DNA.mutation.detection.and.informa-
tion.about.speciic.DDR.gene.sequences.can.be.determined.using.gold.nanoparticles.(Au-NP).and.ion-sensitive.
ield-effect.transistors.(ISFETs)..These.nano-based.technologies.could.play.a.pivotal.role.in.the.future.of.person-
alized.treatments.to.prevent.and.treat.diseases.like.cancer.

understanding.of.the.early.events.associated.with.the.DNA.damage.response..Furthermore.
these. nanotechnology.tools.will.also. enhance.our. understanding. and.detection. of. early.
cellular.events.that.might.contribute.to.diseases.like.cancer.(Figure.6.3)..Armed.with.this.
information,. physicians. would. know. when. to. implement. disease-prevention. strategies.
(i.e.,.antioxidant.or.chelation.therapies).and.when.it.is.appropriate.to.start.cancer.screening.
regimes.aimed.at.detecting.this.disease.in.its.early,.hence,.more.curative,.stage.

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