Biomedical Engineering Reference
In-Depth Information
Scalability.and,.indeed,.a.paradigm.shift.into.self-assembling.manufacturing.environ-
ments.require.innovative.strategies.and.an.interdisciplinary.effort.that.combines.biology.
with.nanotechnology,.engineering,.materials.science,.biophysics,.and.computational.and.
mathematical. modeling. as. well. as. some. nontraditional. partners. in. the. ields. of. art. and.
architecture. to. provide. a. beneicial. “disruptive”. force. to. traditional. thinking.. Scientiic.
discovery.and.advances.closely.follow.technology..The.need.to.visualize.matter.and.tem-
poral. events. of. matter. at. the. nano. scale. (1-100.nm). is. driving. the. development. of. novel.
superresolution.microscopy.systems.and.luorescent.dyes.optimized.for.temporal.viewing.
by.on/off.switching.(Chi,.2009;.Leung.and.Chou,.2011).
The. rate. at. which. technological. incorporation. of. molecular. motors. and. their. tracks.
into.future.devices.becomes.standard.practice.will.be.largely.dictated.by.the.capacity.of.
researchers. to. develop. innovative. strategies. for. harnessing. what. has. been. set. forth. by.
nature..This.will.be.enhanced.as.precise.mechanistic.details.of.cellular.machines.become.
available,.allowing.device.design.to.move.rapidly.from.the.current.heavy-handed.approach.
to.more.dynamic,.eficient,.and.elegant.processes.largely.independent.of.human.interven-
tion..Based.on.what.we.know.of.motor-based.systems.in.cells.that.vary.in.both.spatial.and.
temporal.dimensions.at.the.nanoscale,.a.grand.number.of.applications.will.be.accessible.
References
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Agarwal,.A..and.Hess,.H..(2010)..Biomolecular.motors.at.the.intersection.of.nanotechnology.and.poly-
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Ahringer,.J..(2003)..Control.of.cell.polarity.and.mitotic.spindle.positioning.in.animal.cells.. Current
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Asbury,.C..L.,.Fehr,.A..N.,.and.Block,.S..M..(2003)..Kinesin.moves.by.an.asymmetric.hand-over-hand.
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Betapudi,.V..(2010)..Myosin.II.motor.proteins.with.different.functions.determine.the.fate.of.lamelli-
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