Biomedical Engineering Reference
In-Depth Information
TABLe 4.2 (continued)
Kinesin.and.Kinesin-Like.Protein.Motor.Parameters
Motor
Structure
Velocity In
Vitro (μm/min)
Force
Generation
Motor Source
Direction
Processivity
Effect of Neck Domain
References
Homotetramer
X. laevis
.Eg5;.Kinesin.5
Plus-end
Quasiprocessive;.
Run.length.
∼580.nm
∼0.6-2.4;.8.nm.
steps
Stiff.neck.linker.binds.motor.
domain;.increases.motility;.
provides.plus-end.
directionality;.essential.for.
force.production
N/A
Kwok.et.al..
(2006);.Kapitein.
et.al..(2005);.
Valentine.and.
Gilbert.(2007)
Homotetramer
H. sapiens
.Eg5.(values.
given.are.for.dimeric.
HuEg5-513-5-His.
recombinant.
construct);.Kinesin.5
Plus-end
Quasiprocessive;.
Ave..
displacement.=.
67.±.7.nm;.Ave..
steps/run.=.8.3
∼0.6-2.4;.8.nm.
steps
Rigid.inlexibility.of.neck.
linker.(oriented.
perpendicularly.to.MT);.
causes.change.in.particulars.
of.force.production.in.
comparison.to.conventional.
kinesin
4-7.pN
Valentine.et.al..
(2006)
Monomer
Murine.KIF1A;.
kinesin.3
Bidirection..
neuronal
Highly.
processive;.
11.μm.for.11.±.
7.1.s
∼42.on.
cultured.
neurons
Neck.and.linker.absent.
(monomeric);.exhibits.
bidirectional.motile.
capabilities
N/A
Lee.et.al..(2003);.
Okada.and.
Hirokawa.
(1999)
MT,.microtubule.
