Biomedical Engineering Reference
In-Depth Information
Kinesin.
ppK124-Δ-tail
Glide;.docked.kinesin.
motors.as.a.high-
density,.uniform.sheet;.
highly.functionalized.
MTs
MTs.functionalized.with.
biotin/streptavidin.
associate.noncovalently.and.
align.parallely.over.a.
high-density.surface.of.
adsorbed.motors;.motors.
leave.only.tips.of.MTs.free,.
allowing.MT.bundles.to.
curve.and.form.circular.
structures
Self-assembly.of.nanowires.
and.nanospools.for.NEMS,.
MEMS.devices.(may.
function.as.interconnects.or.
other.key.components)
Experimentally.proven.(10,000.
MT.spools.in.under.an.hour;.
as.big.as.5.μm.in.diameter);.not.
yet.incorporated.into.practical.
device
Hess.et.al..
(2005)
Kinesin
Glide;.docked.kinesin.
motors.in.high.density;.
functionalized.MTs.
bind.to.functionalized.
DNA.to.either.be.
guided.or.to.stretch.
out.DNA.coils
One.end.of.a.coiled.λ-phage.
DNA.strand.is.biotinylated.
to.associate.with.
functionalized.MTs.being.
transported.by.adsorbed,.
high-density.motors;.coiled.
DNA.bound.by.opposite.
end.(also.biotinylated).to.a.
surface.ultimately.stretches.
out
Linear.DNA.molecules.may.
be.stretched.out.on.a.chip.by.
way.of.molecular.shuttles.or.
assembled.into.more.
complex.structures;.may.
serve.as.templates.for.
nanowire.deposition.to.
self-assemble.interconnects
Experimentally.viable;.requires.
technical.reinement.before.
incorporation.into.device
Diez.et.al..
(2003)
Myosin
Glide;.docked.myosin.
motors
Actin.subunits.labeled.with.
Au.nanoparticles;.catalytic.
enlargement.of.
nanoparticles.occurs;.
polymerization.of.actin.
subunits.into.microilaments.
over.adsorbed.myosin.
motors.constructs.gold.
nanowires.(up.to.4.μm.long.
and.200.nm.high)
Self-assembly.of.highly.
conductive.nanowires.for.
nano.circuitry.devices.
(NEMS,.MEMS,.lab-on-a-
chip);.reined.deposition.of.
Au-labeled.subunits.may.
result.in.assembly.of.more.
complex.architectures
Experimentally.proven;.
nanowires.have.been.
assembled.in.this.fashion;.high.
electrical.conductivity.
exhibited
Patolsky.et.al..
(2004)
(continued)
