Biomedical Engineering Reference
In-Depth Information
CH
2
CH
2
CH
2
CH
2
CH
2
O
O
O
O
O
OH
OH
OH
OH
OH
O
O
O
O
O
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
Dextran
CH
2
CH
2
CH
2
CH
2
CH
2
O
O
O
O
O
OH
OSiMe
3
OSiMe
3
OSiMe
3
OSiMe
3
O
O
O
O
O
OSiMe
3
OSiMe
3
OSiMe
3
OSiMe
3
OH
OSiMe
3
OSiMe
3
OH
OSiMe
3
OSiMe
3
t-BuOK/THF
CH
2
CH
2
CH
2
CH
2
CH
2
O
O
O
O
O
OSiMe
3
OSiMe
3
OSiMe
3
OSiMe
3
OK
O
O
O
O
O
OSiMe
3
OSiMe
3
OSiMe
3
OSiMe
3
OSiMe
3
OH
OSiMe
3
OSiMe
3
OSiMe
3
OK
1. Lactide/THF
2. H
+
O
O
O
O
O
O
O
O
O
O
O
O
CH
2
CH
2
CH
2
CH
2
CH
2
O
O
O
O
O
O
OH
OH
OH
OH
O
O
O
O
O
OH
OH
OH
OH
OH
OH
OH
O
OH
OH
O
O
O
O
Dex-
g
-PLA
O
O
O
O
O
O
Fig. 5 Synthesis of polylactide-grafted polysaccharide (Dex-
g
-PLA) by trimethylsilyl-protection
method
can be utilized as biodegradable nanogels in aqueous solution (see Sect.
6
)oras
hydrogel-forming biodegradable materials.
Polyglycidol is a polymer having a PEG-like backbone and hydroxyl side chains.
We also synthesized PLA-grafted polyglycidol (polyglycidol-
g
-PLA) using a
“grafting from” method without any protecting groups to give highly grafted
