Biomedical Engineering Reference
In-Depth Information
Fig. 25 Different components of the recombinant HDL-like specific contrast agent for MRI of
atherosclerotic plaques. (Adapted from [
86
])
Fig. 26 MR images of tumors of mice after they were injected with (a) paramagnetic
a
v
b
3-
specific RGD-liposomes and (b) nonspecific paramagnetic RAD-liposomes. (c, d) Fluorescence
microscopy of 10
m
m sections from dissected tumors revealed a distinct difference between tumors
of mice that were injected with RGD-liposomes (c) or RAD-liposomes (d). Vessel staining was
done with an endothelial cell-specific FITC-CD31 antibody. The
red
fluorescence represents the
liposomes and the
green
fluorescence represents blood vessels. RGD-liposomes were exclusively
found within the vessel lumen or associated with vessel endothelial cells (c), whereas
RAD-liposomes (d) were also found outside blood vessels within the tumor (Adapted from [
88
])
paramagnetic
a
v
b
3-specific RGD-liposomes were exclusively found within the
vessel lumen or associated with vessel endothelial cells Fig.
26c
, whereas nonspe-
cific paramagnetic RAD-liposomes Fig.
26
d were also found outside blood vessels
within the tumor.
