Biomedical Engineering Reference
In-Depth Information
Cytocompatible Hydrogel Composed
of Phospholipid Polymers for Regulation
of Cell Functions
Kazuhiko Ishihara, Yan Xu, and Tomohiro Konno
Abstract We propose a cell encapsulation matrix for use with a cytocompatible
phospholipid polymer hydrogel system for control of cell functions in three-
dimensional (3D) cell engineering and for construction of well-organized tissue
in vivo . In cell engineering fields, it is important to produce cells with highly cell-
specific functions. To realize this, we consider that new devices are needed for
cell culture. So, we have designed soft biodevices using a spontaneously forming
and cytocompatible polymer hydrogel system. A water-soluble phospholipid
polymer bearing a phenylboronic acid unit, poly(2-methacryloyloxyethyl phosphory-
lcholine- co - n -butyl methacrylate- co - p -vinylphenylboronic acid) (PMBV), was
prepared. This polymer, in aqueous solution, spontaneously converted to a hydrogel
by addition of poly(vinyl alcohol) (PVA) aqueous solution due to reversible
bonding between the boronate groups in PMBV and the hydroxyl groups in PVA.
K. Ishihara ( * )
Department of Materials Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Department of Bioengineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Center for NanoBio Integration, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Core Research of Evolutional Science and Technology (CREST), Japan Science
and Technology Agency (JST), Chiyoda-ku, Tokyo, Japan
e-mail: ishihara@mpc.t.u-tokyo.ac.jp
Y. Xu
Department of Applied Chemistry, School of Engineering, Bunkyo-ku, Tokyo, Japan
Center for NanoBio Integration, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
T. Konno
Department of Bioengineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Center for NanoBio Integration, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Core Research of Evolutional Science and Technology (CREST), Japan Science
and Technology Agency (JST), Chiyoda-ku, Tokyo, Japan
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