Biomedical Engineering Reference
In-Depth Information
Fig. 12 Cisplatin-loaded micelle developed by Nishiyama et al. [
71
]. Cisplatin is bonded to block
polymers via coordination by carboxylate groups in the core of the micelle
Fig. 13 The structure of
DOX-conjugated PEG-
b
-poly
(aspartic acid) diblock
copolymer. DOX molecules
are covalently bonded to a
diblock copolymer via
hydrazine linkage, which can
be cleaved in acidic
conditions, enabling the
release of DOX in a site-
specific manner
cisplatin-loaded micelle [
71
], in which platinum is coordinated by carboxylate
groups in block copolymers consisting of PEG and polyaspartate (Fig.
12
). DOX
has been also loaded into micelles by chemical conjugation. Bae et al. developed a
novel method for the conjugation of DOX with PEG-
b
-poly(aspartic acid) diblock
copolymers [
72
], via a hydrazine linkage, which enables the release of DOX in
acidic environments such as acidosis and endocytosis. This property facilitates the
stimuli-responsive delivery of the drug (Fig.
13
).
4.4.3
Inorganic Nanoparticles
Inorganic nanoparticles have also attracted interest in the field of drug delivery [
73
].
These inorganic nanoparticles include calcium phosphate, gold, silicon oxide, and
iron oxide. They can be prepared easily with controllable size and can be readily