Biomedical Engineering Reference
In-Depth Information
Fig. 1 PEGylation
technologies. Nonspecific and
irreversible PEGylation is
associated with several
limitations, such as altered
drug properties. To overcome
this problem, a new
generation of PEGylation
technologies that enable
highly specific and reversible
PEGylation have been
developed
Fig. 2 Examples of activated
PEG derivatives commonly
used for PEGylation
terminated PEG derivative. These conventional methods are summarized in Fig.
2
.
Amine-specific and thiol-specific reagents are efficient and afford a good yield of
PEGylated products. These simple methods can be applied to PEGylation of
various molecules. Indeed, several PEGylated drugs have been approved for
