Biomedical Engineering Reference
In-Depth Information
N
a
NH
NH
O
O
N
C
C
O
COOH
CH
2
O
CH
3
COOH
CH
2
O
O
O
O
O
O
O
O
O
O
OH
O
OH
O
OH
OH
OH
NHCOCH
3
OH
NHCOCH
3
n
Ac-HA-Pba
b
Ac-HA
Quenched Pba
Laser
HA receptor
Enzyme
Activated Pba
Nucleus
Mitochondria
3
O
2
1
O
2
Fluorescence
Fig. 16 (a) Chemical structure of HA/photosensitizer conjugate conjugates and (b) strategy for
photodynamic therapy. Reprinted from [
260
] with permission
lysozyme-loaded nanogels showed a sustained release of lysozyme for 1 week
without denaturation in PBS at 37
C (Fig.
17
)[
164
].
Usual PLAs have two enatiomeric forms, PLLA and poly(
D
-lactide) (PDLA),
which are synthesized from LLA and the
D
,
D
-isomer of lactide (DLA), respectively.
It is well known that 1:1 mixture of PLLA and PDLA can form a stable stereocomplex
(SC), which has a higher
T
m
and higher mechanical strength than either of homo-
polymers [
261
]. We reported on the utility of SC formation to enhance the stability of
nanogels. Monodisperse SC nanogels were obtained through the self-assembly of an
equimolar mixture of Dex-
g
-OLLA and Dex-
g
-ODLA in a dilute aqueous solution.