Biomedical Engineering Reference
In-Depth Information
N
a
NH
NH
O
O
N
C
C
O
COOH
CH 2 O
CH 3
COOH
CH 2 O
O
O
O
O
O
O
O
O
O
OH
O
OH
O
OH
OH
OH
NHCOCH 3
OH
NHCOCH 3
n
Ac-HA-Pba
b
Ac-HA
Quenched Pba
Laser
HA receptor
Enzyme
Activated Pba
Nucleus
Mitochondria
3 O 2
1 O 2
Fluorescence
Fig. 16 (a) Chemical structure of HA/photosensitizer conjugate conjugates and (b) strategy for
photodynamic therapy. Reprinted from [ 260 ] with permission
lysozyme-loaded nanogels showed a sustained release of lysozyme for 1 week
without denaturation in PBS at 37 C (Fig. 17 )[ 164 ].
Usual PLAs have two enatiomeric forms, PLLA and poly( D -lactide) (PDLA),
which are synthesized from LLA and the D , D -isomer of lactide (DLA), respectively.
It is well known that 1:1 mixture of PLLA and PDLA can form a stable stereocomplex
(SC), which has a higher T m and higher mechanical strength than either of homo-
polymers [ 261 ]. We reported on the utility of SC formation to enhance the stability of
nanogels. Monodisperse SC nanogels were obtained through the self-assembly of an
equimolar mixture of Dex- g -OLLA and Dex- g -ODLA in a dilute aqueous solution.
Search WWH ::




Custom Search