Biomedical Engineering Reference
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The building blocks were coupled to the corresponding lipids
and functionalized polyamine-building blocks used for the synthesis
of RPR120535 (Figs. 1.3 and 1.4), by successive peptide couplings
and deprotection of Boc groups. The structures of the compounds
are drawn in Fig. 1.14.
Obtained from scaffold 1
Reduction site
RPR128522
O
N
N
S
N
N
S
N
N
O
Obtained from scaffold 2
RPR132621
O
N
N
N
N
N
N
O
S
S
O
N
N
N
N
N
N
O
Obtained from scaffold 3
RPR132535
S
S
O
N
N
N
N
N
N
O
RPR132683
S
S
O
N
N
N
N
N
N
O
RPR132775
S
S
O
N
N
N
N
N
N
O
RPR132688
S
S
O
N
N
N
N
N
N
O
RPR132776
S
S
O
N
N
N
N
N
N
O
RPR202065
O
N
N
N
N
N
N
O
S
S
Figure 1.14
Structure of reduction-sensitive lipopolyamines.
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