Biomedical Engineering Reference
In-Depth Information
of leukocyte-associated malignancies, given that in addition to
targeting the cancer cells in the peripheral blood system, the
hematopoietic cancer cells should also be targeted to prevent the
relapse of the disease; this additional targeting requires the use of
different siRNAs and targeting molecules. The I-tsNP system that was
developed for the delivery of siRNAs to “challenging” hematopoietic
cells meets all the requirements from a delivery-vehicle standpoint;
as delivery is highly specific and has high payload capability, siRNAs
are protected from degradation and toxic effects are not induced at
the doses used. Moreover, when administrated systemically, I-tsNP-
delivered siRNAs are capable of silencing gene expression with a
relatively low amount of siRNAs, making this method economically
viable. However, further studies are required to translate this
delivery system into the clinical setting.
Acknowledgments
I would like to thank my lab members for helpful discussions.
This work was supported in part by grants from the Marie Curie
IRG-FP7 of the European Union, Lewis Family Trust, Israel Science
Foundation (Award #181/10), the Israel-US Bi-national foundation,
the Kenneth Rainin Foundation, the I-CORE Program of the Planning
and Budgeting Committee and The Israel Science Foundation
(grant No
), and the FTA: Nanomedicines for Personalized
Theranostics of the Israeli National Nanotechnology Initiative to
D.P.
41/11
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