Bioresponsive Nanoparticles for the Intracellular Delivery of RNAi Therapeutics - Nanotechnology for the Delivery of Therapeutic Nucleic Acids - page 145

modification can be used to control cellular uptake, intracellular
trafficking, and nanoparticle disassembly. Furthermore, these
properties may offer the possibility to modulate the level and duration
of RNAi activity. The structural-activity relationship exhibited by
the polymers described in this work highlights the importance of
polymer design for development of next-generation multifunctional
delivery systems for RNAi therapeutics.

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