Biomedical Engineering Reference
In-Depth Information
biological environment such as cell culture medium. Two factors
may inluence cell growth on the disks: adsorbing protein onto the
disks and released metal ions from the disks (see Table 12.5).
45
40
35
b
30
a
25
20
15
10
5
0
50%
25%
12.50%
6.25%
extract fraction
Figure 12.9
Cytotoxicity tests of the extracts of studied samples:
(a) microcrystalline titanium, (b) Ti-10 vol% 45S5 Bioglass
in dynamic conditions (see text for details).
Table 12.5
Quantiications of metallic elements in the extracts in
microcrystalline titanium and nanocomposite Ti-10 vol%
45S5 Bioglass (<DL - concentration below detection level)
Sample
Microcrystalline Ti
[mg/L]
Ti-10 vol% 45S5 Bioglass
[mg/L]
Element
Ca
64 ± 8
82 ± 11
Cr
4.4 ± 0.7
4.1 ± 0.6
P
0
0
Ti
<DL
<DL
The quantiication of metallic elements in each extract of studied
nanocomposite Ti-45S5 Bioglass samples was performed for the
elements such as Ca, Cr, P, and Ti under the optimum condition for
each element and the results are shown in Table 12.5. In all extracts,
chromium was detected at the concentration of 4.4 ± 0.7 and
