Harnessing Cell–Biomaterial Interactions for Osteochondral Tissue Regeneration - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 68

GAG Glycosaminoglycan

GMP Gelatin microparticle

IGF Insulin-like growth factor

MDSC Muscle-derived stem cell

MMP Matrix metalloproteinase

MSC Mesenchymal stem cell

OPF Oligo(poly(ethylene glycol) fumarate)

PCL Poly(e-caprolactone)

PDSC Periosteum-derived stem cell

PEG Poly(ethylene glycol)

PHA Poly(hydroxyalkanoate)

PLGA Poly( L , D -lactic-co-glycolic acid)

RGD Arg-Gly-Asp

mRNA Messenger RNA

TGF Transforming growth factor

Contents

1 Introduction.......................................................................................................................... 69

2 Background .......................................................................................................................... 69

3 Cartilage............................................................................................................................... 70

3.1 Chondrocytes............................................................................................................... 70

3.2 Extracellular Matrix.................................................................................................... 71

3.3 Architecture................................................................................................................. 2

4 Chondrocyte-ECM Interactions.......................................................................................... 73

5 Cell Sources for Cartilage Tissue Engineering .................................................................. 74

5.1 Stem/Progenitor Cell Sources .................................................................................... 74

5.2 Fibroblasts ................................................................................................................... 79

6 Chondrogenesis in Biomaterials ......................................................................................... 80

6.1 Cell Homing................................................................................................................ 80

6.2 Hydrogels .................................................................................................................... 1

7 Modification of Biomaterials .............................................................................................. 82

7.1 RGD Peptide Incorporation........................................................................................ 82

7.2 Growth Factor Incorporation ...................................................................................... 84

7.3 Gene Delivery ............................................................................................................. 86

7.4 Modulation of the Intrinsic Properties of Biomaterials ............................................ 87

8 Osteochondral Tissue Regeneration.................................................................................... 90

8.1 Zonal Cartilage Engineering ...................................................................................... 90

8.2 Bilayered Hydrogels ................................................................................................... 91

9 Summary .............................................................................................................................. 93

References.................................................................................................................................. 93