Studying Cell–Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 63

Table 1 (continued)
Technique

Information provided Substrate Strength Limitation

ECIS
Electrochemical

Cell spreading kinetics,
micromotility of adherent cells,
migration velocity in wound
healing assay

planar gold film electrodes • label-free and non-

invasive

• restricted to conducting and
electrochemically well-behaved
electrode materials • 96 samples in parallel

• sensitive to cell morphology as
competing signal contribution

• automated assay
• real time approach

QCM Acoustic Cell spreading kinetics,

micromechanics of cell-
surface junction, shear
resistance of cell-surface
interactions

piezoelectric quartz crystal
sandwiched between two
gold film electrodes

• label-free and non-
invasive

• limited parallelization
• sensitive to cellular micromechanics
as competing signal contribution • real time approach

• resonator can be
coated with any thin
and rigid material