The Cell–Surface Interaction - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 25

5 Summary and Conclusions

The cell-material interaction is a complex interplay of a variety of biological
processes that are differentially influenced by changes in surface properties,
in particular surface microtopography. Alterations on a microscale and even a
nanoscale to a surface have been shown to directly impact on initial adhesion to
nuclear signal transduction and ultimately influence cell phenotype. Although
many details regarding the exact mechanisms involved in this substrate-dependent
control are still under investigation, a wealth of information has emerged that has
been useful in refining an empirical approach towards biomaterial development for
determining specific cell and tissue responses. Nevertheless, with the development
of new, more sensitive analytical techniques and refinement of fabrication pro-
cesses, additional valuable information is yet to emerge. As this happens, the realm
of biologic-biomaterial interaction research will undoubtedly welcome a influx of
novel approaches that will potentially expand the application of this technology
beyond orthopaedic medicine.

References

1. Kasemo B, Lausmaa J (1994) Material-tissue interfaces: the role of surface properties and
processes. Environ Health Perspect 102(5):41-45
2. Kasemo B, Gold J (1998) Implant surfaces and interface processes. Adv Dent Res 13:8-20
3. Richards RG (2008) The relevance of implant surfaces in hand fracture fixation. In:
Osteosynthesis in the hand: current concepts. FESSH instructional course 2008. Karger,
Basel, pp 20-30
4. Probst A, Speigel HA (1997) Cellular mechanisms of bone repair. J Invest Surg 10:77-86
5. Schindeler A, McDonald MM, Bokko P, Little DG (2008) Bone remodeling during fracture
repair: the cellular picture. Semin Cell Dev Biol. doi:10.1016/j.semcdb.2008.07.004
6. Deuel TF, Senior RM, Huang JS, Griffin GL (1982) Chemotaxis of monocytes and
neutrophils to platelet-derived growth factor. J Clin Invest 69:1046-1049
7. Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH (1987) Stimulation of the chemotactic
migration of human fibroblasts by transforming growth factor beta. J Exp Med 165:251-256
8. Togrul E, Bayram H, Gulsen M, Kalaci A, Ozbarlas S (2005) Fractures of the femoral neck
in children: long-term follow up in 62 hip fractures. Injury 36:123-130
9. Schmalzreid TP, Grogan TJ, Neumeier PA, Dorey FJ (1991) Metal removal in a pediatric
population: benign procedure or necessary evil? J Pediatr Orthop 11:72-76
10. Kahle WK (1994) The case against routine metal removal. J Pediatr Orthop 14:229-237
11. Hamilton P, Doig S, Williamson O (2004) Technical difficulty of metal removal after LISS
plating. Injury 35:626-628
12. Ruoslahti E (1991) Integrins. J Clin Invest 87(1):1-5
13. Xiao G, Wang D, Benson MD, Karsenty G, Franceschi RT (1998) Role of the alpha2-
integrin in osteoblast-specific gene expression and activation of the Osf2 transcription
factor. J Biol Chem 273(49):32988-32994
14. Petrie TA, Raynor JE, Dumbauld DW, Lee TT, Jagtap S, Templeman KL, Collard DM,
García AJ (2010) Multivalent integrin-specific ligands enhance tissue healing and

biomaterial integration. Sci Transl Med 2(45):45-60