The Cell–Surface Interaction - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 24

(a)
(b)
(c)
(d)
Fig. 7 Stepwise production of mineralized matrix at the implant interface. a Secretion of the
non-collagenous proteins osteopontin and bone sialoprotein. b Calcium phosphate nucleation at
calcium binding sites. c Crystal growth and propagation. d Collagen production and
mineralization with matrix separated from the substratum by a collagen-free calcified tissue
layer (approximately 0.5 lm). (Modified from [ 111 ])