Interaction ofCartilage andCeramic Matrix - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 297

Interaction of Cartilage and Ceramic Matrix

K. Wiegandt, C. Goepfert, R. Pörtner and R. Janssen

Abstract As subchondral bone is often affected during cartilage injuries, the aim
of research is to generate osteochondral implants in vitro using tissue engineering
techniques. These constructs consist of a cartilage layer grown on top of a bone
phase. In clinical applications, phosphate ceramics have gained acceptance
as bone substitute materials because of their great affinity to natural bone.
Furthermore, the interaction between cartilage and the underlying bone equiva-
lent is essential for the development and success of osteochondral implants. Here,
the influence of a carrier containing hydroxyapatite on the quality of cartilage
constructs generated in vitro is investigated. Attempts are made to explain
the effects described, by considering chemical and physical properties of the
biomaterial.

Keywords Bioceramics Cartilage Hydroxyapatite Osteochondral implants
Surface structure

Contents

1 Introduction........................................................................................................................ 298

2 Relevant Substrate Properties for Tissue Engineering..................................................... 299

3 Impact of a Hydroxyapatite Carrier on Cartilage Formation .......................................... 300

4 Time Course of Cartilage Formation................................................................................ 305

5 Impact of Surface Structure .............................................................................................. 307

6 Conclusion ......................................................................................................................... 311

References................................................................................................................................ 312

K. Wiegandt R. Janssen ( )

Institute of Advanced Ceramics, Hamburg University of Technology,
Hamburg, Germany
e-mail: [e-mail]
C. Goepfert R. Pörtner
Institute of Bioprocess and Biosystems Engineering,
Hamburg University of Technology, Hamburg, Germany

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